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Leroy L. Cooper Assistant Professor of Biology

My research interests lie in investigating the leading cause of death in the world: cardiovascular disease. Arterial stiffening and abnormal vascular hemodynamics with advancing age are associated with increased cardiovascular and cerebrovascular events, including premature death. In light of a rapid aging of the world population, the burden of cardiovascular disease, and its associated disorders, will increase substantially over the next years. As such, novel therapeutic and preventative measures are necessary to limit or reduce arterial stiffening and downstream target organ damage with advancing age. Using a population-based approach, my research seeks to examine the associations of abnormal hemodynamics and adverse cardiovascular and cerebrovascular outcomes in order to elucidate potential targets for treatment and prevention.

  • BS, Clemson University; AM, PhD, Brown University; MPH, Harvard University
  • At Vassar since 2016

Contact

Research and Academic Interests

  • Epidemiology and public health
  • Cardiovascular physiology
  • Arterial stiffness and vascular hemodynamics
  • Target organ damage
  • Vascular brain injury

Courses

  • BIOL 108. Information Flow in Biological Systems
  • STS 268. Current and Emerging Issues in Public Health
  • BIOL 288. Epidemiology
  • BIOL 389. Cardiovascular Physiology and Epidemiology
  • BIOL/STS 393. Biology in the Community (Public Health)

Selected Publications

  • Cooper LL, Musani SK, Moore JA, Clarke VA, Yano Y, Cobbs K, Tsao CW, Butler J, Hall ME, Hamburg NM, Benjamin EJ, Vasan RS, Mitchell GF, and Fox ER. Clinical associations of vascular stiffness, microvascular dysfunction, and prevalent cardiovascular disease in a black cohort: the Jackson Heart Study. J Am Heart Assoc. 2020;9(18):e017018. [PMID: 32873113].
  • Cooper LL and Mitchell GF. Incorporation of novel vascular measures into clinical management: recent insights from the Framingham Heart Study. Curr Hypertens Rep. 2019;21(2):19. [PMID: 30790125]. (Review).
  • Cooper LL, Musani SK, Washington F, Moore J, Tripathi A, Tsao CW, Hamburg NM, Benjamin EJ, Vasan RS, Mitchell GF, and Fox ER. (2018). Relations of microvascular function, cardiovascular disease risk factors, and aortic stiffness in blacks: the Jackson Heart Study. J Am Heart Assoc7(20):e009515. [PMID: 30371273]. 
  • Nayor M, Cooper LL, Enserro DM, Xanthakis V, Larson MG, Benjamin EJ, Aragam J, Mitchell GF, and Vasan RS. (2018). Left ventricular diastolic dysfunction in the community: impact of diagnostic criteria on the burden, correlates, and prognosis. J Am Heart Assoc. 7(11):e008291. [PMID: 29858363].
  • Cooper LL, Himali JJ, Torjesen A, Tsao CW, Beiser A, Hamburg NM, DeCarli C, Vasan RS, Seshadri S, Pase MP, and Mitchell GF. (2017). Inter-relations of orthostatic blood pressure change, aortic stiffness, and brain structure and function in young adults. J Am Heart Assoc. 6(8):e006206. [PMID: 28862943].
  • Torjesen A, Cooper LL, Rong J, Larson MG, Hamburg NM, Levy D, Benjamin EJ, Vasan RS, and Mitchell GF. (2017). Relations of arterial stiffness with postural change in mean arterial pressure in middle-aged adults: the Framingham Heart Study. Hypertension. 69(4):685-690. [PMID: 28264924].
  • Cooper LL, Palmisano JN, Benjamin EJ, Larson MG, Levy D, Vasan RS, Mitchell GF, and Hamburg NM. (2016). Microvascular function mediates relations between aortic stiffness and cardiovascular events. Circ Cardiovasc Imaging. 9(12):e004979. [PMID: 27956408].
  • Cooper LL, Woodard T, Sigurdsson S, van Buchem MA, Torjesen AA, Levey AS, Inker LA, Aspelund T, Eiriksdottir E, Harris TB, Gudnason V, Launer LJ, and Mitchell GF. (2016). Cerebrovascular damage mediates relations between aortic stiffness and memory. Hypertension. 67:176-182. [PMID: 26573713].
  • Cooper LL, Rong J, Benjamin EJ, Larson MG, Levy DL, Vita JA, Hamburg NM, Vasan RS, and Mitchell GF. (2015). Components of hemodynamic load and cardiovascular events: the Framingham Heart Study. Circulation. 131(4):354-361. [PMID: 25416177].

[Additional Publications]

 

Photos

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Photo: Carlisle Stockton / Vassar College
  • Postdoctoral Fellow, Lifespan Cardiovascular Institute, Providence, RI, and Cardiovascular Engineering, Inc., Norwood, MA
  • MPH, Quantitative Methods (Epidemiology and Biostatistics), Harvard University, T. H. Chan School of Public Health, Boston, MA
  • PhD, Molecular Pharmacology and Physiology, Brown University, Providence, RI
  • BS, Biochemistry and Sociology, Clemson University, Clemson, SC

Research Summary

My research interests lie in investigating the leading cause of death in the world: cardiovascular disease. Arterial stiffening and abnormal vascular hemodynamics with advancing age are associated with increased cardiovascular and cerebrovascular events, including premature death. In light of a rapid aging of the world population, the burden of cardiovascular disease, and its associated disorders, will increase substantially over the next years. As such, novel therapeutic and preventative measures are necessary to limit or reduce arterial stiffening and downstream target organ damage with advancing age. Using a population-based approach, my research seeks to examine the associations of abnormal hemodynamics and adverse cardiovascular and cerebrovascular outcomes in order to elucidate potential targets for treatment and prevention.