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Leroy L. Cooper Assistant Professor of Biology

Cardiovascular disease (CVD) is the leading cause of death in the United States. Increased arterial stiffening and abnormal vascular hemodynamics with advancing age are associated with increased CVD related events including death. In light of a rapid aging of the world population, the burden of CVD, and its associated disorders, will increase substantially over the next years. As such, novel therapeutic and preventative measures are necessary to limit or reduce aortic stiffening with advancing age. Using a population-based approach, my research seeks to examine the associations of vascular hemodynamic load with CVD in order to elucidate potential targets for treatment and prevention.

  • BS, Clemson University; AM, PhD, Brown University; MPH, Harvard University
  • At Vassar since 2016

Contact

  • Phone: 845-437-7928
  • Office: Olmsted Hall of Biological Sc
  • Hours: Tuesdays and Thursdays, 1:30-3pm and by appointment (Fall 2018)
  • Box: 70

Research and Academic Interests

  • Cardiovascular Physiology
  • Epidemiology and Public Health
  • Cell and Molecular Physiology

Courses

  • BIOL 106. Introduction to Biological Investigation
  • STS 268. Current and Emerging Issues in Public Health
  • BIOL 288. Epidemiology
  • BIOL 389. Cardiovascular Physiology and Epidemiology

Selected Publications

  • Cooper LL, Himali JJ, Torjesen A, Tsao CW, Beiser A, Hamburg NM, DeCarli C, Vasan RS, Seshadri S, Pase MP, and Mitchell GF. (2017). Inter-relations of orthostatic blood pressure change, aortic stiffness, and brain structure and function in young adults. J Am Heart Assoc. 6(8):e006206. [PMID: 28862943]
  • Torjesen A, Cooper LL, Rong J, Larson MG, Hamburg NM, Levy D, Benjamin EJ, Vasan RS, and Mitchell GF. (2017). Relations of arterial stiffness with postural change in mean arterial pressure in middle-aged adults: the Framingham Heart Study. Hypertension. 69(4):685-690. [PMID: 28264924].
  • Cooper LL, Palmisano JN, Benjamin EJ, Larson MG, Levy D, Vasan RS, Mitchell GF, and Hamburg NM. (2016). Microvascular function mediates relations between aortic stiffness and cardiovascular events. Circ Cardiovasc Imaging. 9(12):e004979. [PMID: 27956408].
  • Cooper LL and Mitchell GF. (2016). Aortic stiffness, cerebrovascular dysfunction, and memory: a mini-review. Pulse (Basel). 4(2-3):69-77. Review. [PMID: 27752478].
  • Cooper LL, Woodard T, Sigurdsson S, van Buchem MA, Torjesen AA, Levey AS, Inker LA, Aspelund T, Eiriksdottir E, Harris TB, Gudnason V, Launer LJ, and Mitchell GF. (2016). Cerebrovascular damage mediates relations between aortic stiffness and memory. Hypertension. 67:176-182. [PMID: 26573713].
  • Cooper LL, Rong J, Benjamin EJ, Larson MG, Levy DL, Vita JA, Hamburg NM, Vasan RS, and Mitchell GF. (2015). Components of hemodynamic load and cardiovascular events: The Framingham Heart Study. Circulation. 131(4):354-361. [PMID: 25416177].

[Additional Publications]

 

Photos

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Photo: Karl Rabe / Vassar College
  • Postdoctoral Fellow, 2013 - 2016, Lifespan Cardiovascular Institute, Providence, RI, and Cardiovascular Engineering, Inc., Norwood, MA
  • MPH, 2016, Quantitative Methods (Epidemiology and Biostatistics), Harvard University, T. H. Chan School of Public Health, Boston, MA
  • PhD, 2013, Molecular Pharmacology and Physiology, Brown University, Providence, RI
  • BS, 2005, Biochemistry and Sociology, Clemson University, Clemson, SC

Research Interests

Cardiovascular Physiology and Epidemiology; Vascular Stiffness; Microvascular Function; Cerebrovascular Disease; Aging; Health Disparities; and Cardiac Electrophysiology and Arrhythmia

Summary: Cardiovascular disease (CVD) is the leading cause of death in the United States. Increased arterial stiffening and abnormal vascular hemodynamics with advancing age are associated with increased CVD related events including death. In light of a rapid aging of the world population, the burden of CVD, and its associated disorders, will increase substantially over the next years. As such, novel therapeutic and preventative measures are necessary to limit or reduce aortic stiffening with advancing age. Using a population-based approach, my research seeks to examine the associations of vascular hemodynamic load with CVD in order to elucidate potential targets for treatment and prevention.

Teaching Interests

Physiology; Public Health; Epidemiology; Cardiovascular Physiology; and Cell and Molecular Physiology

Courses: BIOL 106 Introduction to Biological Investigation; BIOL 288 Epidemiology; BIOL 389 Cardiovascular Physiology and Epidemiology; and STS 268 Current and Emerging Issues in Public Health